Sermorelin

What is it?

Sermorelin is the natural first 29 amino acids of growth hormone-releasing hormone (GHRH), the body’s own signal to release growth hormone from the pituitary gland. It was previously FDA-approved but has since been commercially discontinued as a licensed medicine.

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Key Benefits (from research)

– Restores growth hormone pulses in older men – A controlled study in men aged 64-76 showed significant increases in night-time GH release alongside improvements in muscle strength and endurance.

– Works with your body’s natural rhythms – Like other GHRH-class compounds, it preserves the pulsatile pattern of GH release rather than delivering a flat dose.

– Boosts immune function in ageing – A 6-month study in older adults showed improvements in T-lymphocyte function and related immune cell activity after GHRH treatment.

– Supports body composition – Reviews link GHRH-class stimulation to improved lean mass and reduced body fat in populations with declining GH.

– Useful as a diagnostic tool – Sermorelin was historically used to test whether poor GH secretion was due to the pituitary gland or the hypothalamus.

– Well-characterised metabolic profile – Validated detection methods and metabolite data are published, making it a well-understood reference compound in GH research.

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Quick Q&A

What is Sermorelin used for in research?
It is studied for its ability to restore growth hormone pulsatility, support immune function in ageing, and improve body composition in research models of GH decline.

Is it approved for people?
Sermorelin was previously FDA-approved as Geref but has been commercially discontinued. The reference compound here is for laboratory use only and is not an approved medicine. It is not MHRA-approved in the UK.

Important Notice
Sold for laboratory research only. Not for human use. Must be 18+.

More information
Sermorelin is a synthetic analogue of the first 29 amino acids of human growth hormone-releasing hormone (GHRH). It stimulates the pituitary to produce and secrete growth hormone via GHRH receptors. Studied extensively in models of GH deficiency, pituitary function, and age-related GH decline. Supplied as lyophilised acetate salt. For laboratory research use only.