Tesamorelin

What is it?

Tesamorelin is a stabilised form of growth hormone-releasing hormone that has been approved by the FDA for reducing excess belly fat in HIV patients. The research reference compound on this page is for laboratory use only and is not the prescription medicine.

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Key Benefits (from research)

– Reduces visceral (belly) fat – Two Phase 3 trials in over 800 patients showed approximately 17.5% reduction in deep abdominal fat over 52 weeks.

– Reduces liver fat — A clinical trial demonstrated significant reductions in liver fat, the first evidence of this effect for a growth hormone-type compound.

– Preserves lean tissue – A meta-analysis of five trials confirmed significant lean body mass gains alongside fat loss.

– Lowers triglycerides – Phase 3 trials documented meaningful improvements in blood fat levels alongside fat loss.

– Works through the body’s own pathways — Unlike direct growth hormone injections, it preserves the natural feedback system, giving a more controlled hormonal response.

– Liver disease research – A dedicated 12-month trial in patients with fatty liver disease confirmed reduced liver fat, extending research interest beyond HIV.

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Quick Q&A

What is Tesamorelin used for in research?
It is studied for reducing visceral and liver fat, improving body composition, and lowering cardiovascular risk markers via growth hormone axis stimulation.

Is it approved for people?
Yes it is FDA-approved as Egrifta for HIV-associated lipodystrophy in the United States. It is not MHRA-approved in the UK. The compound sold here is a research reference only, not the approved medicine.

Important Notice
Sold for laboratory research only. Not for human use. Must be 18+.

More Information
Tesamorelin is a synthetic analogue of human GHRH in which a trans-3-hexenoic acid group is conjugated to the N-terminus of GHRH(1-44)-NH2, significantly improving stability. It stimulates endogenous GH secretion by binding to pituitary GHRH receptors. Of significant research interest for its effects on visceral adipose tissue in preclinical models. For laboratory research use only.