5-Amino-1MQ

Also known as: 5-amino-1-methylquinolinium, NNMTi

What is it?

5-Amino-1MQ is a small molecule that blocks an enzyme called NNMT, which is highly active in fat tissue. By blocking NNMT, it nudges fat cells to burn more energy and store less fat without affecting appetite. All current evidence is from animal and cell studies; no human trials have been published.

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Key Benefits (from research)

– Reduces body fat without changing appetite – Preclinical studies showed significant reductions in body weight and fat mass with no change in food intake.

– Raises NAD+ and SAM levels – Blocking NNMT diverts nutrients into the cell’s energy- making and gene-regulation systems, raising levels of both NAD+ and SAM.

– Genetic validation of the target — A landmark study confirmed that disabling NNMT in fat tissue alone was enough to protect mice from obesity, validating the mechanism.

– Works synergistically with reduced-calorie diets – Combining 5-Amino-1MQ with a low- calorie diet produced faster fat and weight loss than diet alone in animal models.

– Remodels the gut microbiome — Animal studies found distinct changes in gut bacteria composition compared to controls, with increases in bacteria linked to healthy weight.

– Improves insulin sensitivity – Multiple animal studies document improved insulin sensitivity and glucose tolerance alongside fat loss.

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Quick Q&A

What is 5-Amino-1MQ used for in research?
It is studied as a novel approach to fat metabolism that reduces fat and raises cellular energy molecules without suppressing appetite. All findings are preclinical.

Is it approved for people?
No — no human trials have been published. It is sold for laboratory research only.

Important Notice
Sold for laboratory research only. Not for human use. Must be 18+.

More information
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that plays a significant role in cellular metabolism and energy homeostasis. By inhibiting NNMT, it may increase SAM and NAD+ availability in cells. Studied in preclinical models of obesity, metabolic syndrome, and muscle mass preservation. For laboratory research use only.