AOD-9604

Also known as: hGH fragment 176–191, Anti-Obesity Drug 9604

What is it?
AOD-9604 is a small fragment taken from the tail end of human growth hormone. Unlike full- length growth hormone, it targets fat metabolism specifically – without triggering growth-related effects.

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Key Benefits (from research)

– Helps break down fat – Research documents a threefold increase in fat release from human fat tissue in vitro and significant increases in fat burning in animal models.

– Boosts energy expenditure – Acute dosing raised energy expenditure by 45% above baseline in obese animal models, attributed to fat oxidation.
Does not raise IGF-1 – A key finding: AOD-9604 does not activate the growth-signalling side of growth hormone, separating its fat-burning effect from growth-related risks.

– Normalises fat-cell receptor expression – Research showed it restored levels of the main fat-burning receptor (beta-3 adrenergic receptor) in obese animals back to normal.

– Human safety data available – Six clinical trials in 925 participants established a favourable safety profile with no significant effects on blood glucose or insulin resistance.

– Cartilage repair research – Animal studies found intra-articular injection improved cartilage regeneration in a knee osteoarthritis model.

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Quick Q&A

What is AOD-9604 used for in research?
It is studied for its ability to increase fat breakdown and energy expenditure without the growth-related effects of full-length growth hormone.

Is it approved for people?
It’s obesity drug programme was discontinued in 2007 after a pivotal trial missed its primary endpoint. It holds food-safe (GRAS) status in the United States. In the UK, it is not approved as a drug and is sold here for laboratory research only.

Important Notice
Sold for laboratory research only. Not for human use. Must be 18+.

More information
AOD-9604 is a modified fragment of human growth hormone (HGH) spanning amino acids 176-191, with a tyrosine addition at the N-terminus. Developed to isolate the lipolytic properties of HGH without the metabolic and proliferative effects of the intact hormone. Studied in preclinical models of fat metabolism and adipogenesis. For laboratory research use only.