MOTS-c

Also known as: Mitochondrial-Derived Peptide, Mitochondrial Open Reading Frame of the 12S rRNA type-c

What is it?
MOTS-c is a tiny peptide that is made inside our mitochondria (the cell’s power generators). During exercise or metabolic stress, it travels to the cell nucleus and switches on genes that support energy use and cellular health. Levels decline with age.

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Key Benefits (from research)

– Improves insulin sensitivity – Preclinical studies in obese mice showed MOTS-c significantly improved insulin resistance and restored key energy-sensing proteins in muscle.

– Acts like exercise in cells – A human study in cancer survivors showed that aerobic exercise raised MOTS-c levels, and higher MOTS-C correlated with less body fat and better metabolic markers.

– Supports energy production in cells — MOTS-c activates AMPK and related pathways, driving better glucose use and fat burning at the cellular level.

– Supports bone health — Research documents MOTS-c promotes bone-forming cells and inhibits bone-breakdown cells, linking it to the bone benefits of physical activity.

– Reduces heart scarring in diabetes — Animal studies show MOTS-C reduces fibrosis in diabetic heart tissue and preserves cardiac function.

– Linked to healthy ageing — Studies in ageing animal models show MOTS-c prevents abnormal fat accumulation and reduces DNA stress markers in multiple tissues.

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Quick Q&A

What is MOTS-c used for in research?
It is studied as a mitochondrial signal involved in insulin sensitivity, exercise adaptation, bone metabolism, cardiac health, and cellular ageing.

Is it approved for people?
No – it is sold for laboratory research only.

Important Notice
Sold for laboratory research only. Not for human use. Must be 18+.

More Information
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide encoded within the mitochondrial genome’s 12S rRNA region. Studied for roles in metabolic regulation, insulin sensitivity, skeletal muscle function, and longevity signalling. MOTS-c translocates to the nucleus in response to metabolic stress to regulate gene expression. For laboratory research use only.