Semaglutide

What is it?

Semaglutide is an appetite-regulating compound that mimics a gut hormone called GLP-1. It signals the brain and pancreas to reduce hunger, improve blood sugar control, and slow digestion. The version sold here is a research reference compound, not the approved medicine.

Key Benefits (from research)

• Significant weight loss – The STEP 1 trial (N=1,961) showed an average 14.9% body weight reduction over 68 weeks; the STEP 5 trial confirmed this was sustained at 2 years.
• Reduces heart attack and stroke risk – The SELECT trial (N=17,604) showed a 20% reduction in major cardiovascular events in people with obesity and heart disease.
• Protects kidney function – The FLOW trial stopped early after semaglutide reduced kidney disease progression by 24% and lowered all-cause mortality by 20%.
• Improves heart failure symptoms – The STEP-HFPEF trial showed significant improvements in exercise capacity, symptoms, and inflammation in heart failure patients.
• Controls blood sugar — Across multiple trials, semaglutide reduced HbA1c by 1.0-1.8 percentage points versus placebo in type 2 diabetes patients.
• Reduces diabetes risk – SELECT trial data showed only 3.5% of semaglutide-treated participants developed new-onset diabetes versus 12% on placebo.

Quick Q&A

What is Semaglutide used for in research?
It is studied for its effects on weight, blood sugar, cardiovascular risk, kidney function, and heart failure – the most extensively trialled peptide on this list.

Is it approved for people?
Yes – under brand names Ozempic and Wegovy by prescription in the UK and US. The compound sold here is a research reference only, not the approved medicine.

More informaton
Semaglutide is a long-acting GLP-1 receptor agonist with a half-life of approximately 7 days due to C-18 fatty diacid albumin-binding modification. Extensively studied in preclinical and clinical models of type 2 diabetes and obesity, and has become one of the most important research peptides in metabolic science. Supplied as a lyophilised research-grade compound. For laboratory research use only.